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Kostyantyn Dumchev
01.06.2014 - 30.11.2018
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute on Drug Abuse (NIDA)
National Institutes of Health (NIH)
The aim of the study is detection of possibility of implementation of further randomized clinic research, which will evaluate if the level of HIV transmission to uninfected partners might be reduced as a result of using integrated approach. Such approach includes psychological consultations and referring to ART and drug abuse treatment for HIV-infected people who inject drugs comparing with standard services, which were developed according to national standards of treatment and preventive measures for HIV-infected people who inject drugs.

Presentations:

Вільям С. Міллер. Проект HPTN 074. Інтегровані підходи до лікування та профілактики серед ЛВІН: перші результати у рамках мережевого рандомізованого клінічного дослідження із профілактики ВІЛ, у яких подано порівняльний аналіз інтегрованих програм, у тому числі контрольованої антиретровірусної терапії, та програм стандартного надання медичної допомоги. 2018 (UA)

HPTN 074 Ukraine Site Progress (EN)

Articles:

Kathryn E Lancaster, Irving F Hoffman, Brett Hanscom, Tran Viet Ha, Kostyantyn Dumchev, et al. Regional differences between people who inject drugs in an HIV prevention trial integrating treatment and prevention (HPTN074): a baseline analysisJournal of the International AIDS Society. Oct 22, 2018 (EN)

William C Miller; Irving F Hoffman; Brett S Hanscom; Tran V Ha; Kostyantyn Dumchev; Zubairi Djoerban; Scott M Rose; Carl A Latkin; David S Metzger; Kathryn E Lancaster; Vivian F Go; Sergii Dvoriak; et al. A scalable, integrated intervention to engage people who inject drugs in HIV care and medication-assisted treatment (HPTN 074): a randomised, controlled phase 3 feasibility and efficacy studyThe Lancet. September 01, 2018 (EN)

Вільям С. Міллер, Ірвінг Ф. Гоффман, Бретт С. Ганском, Тран В. Га, Костянтин Думчев та ін. Розширювана інтегрована інтервенція із залучення осіб, які вживають ін’єкційні наркотики, до програм лікування ВІЛ та медикаментозного підтримуючого лікування наркозалежності (HPTN 074): рандомізоване контрольоване дослідження третьої фази щодо здійсненності та дієвості (Переклад з англ.) The Lancet. September 01, 2018 (UA)

Sugarman J, Barnes M, Rose S, Dumchev K, Sarasvita R, Viet HT, et al. Development and implementation of participant safety plans for international research with stigmatised populations. The lancet HIV. 2018;5(8) (EN)

Fogel JM, Zhang Y, Palumbo PJ, Guo X, Clarke W, Breaud A, et al. Use of Antiretroviral Drug Testing to Assess the Accuracy of Self-reported Data from HIV-Infected People Who Inject Drugs. AIDS and behavior. 2019 (EN)

Kiriazova T., Go V.F., Hershow R.B. et alPerspectives of clients and providers on factors influencing opioid agonist treatment uptake among HIV-positive people who use drugs in Indonesia, Ukraine, and Vietnam: HPTN 074 studyHarm Reduct J, 2020 Oct 01 (EN)

Oleksandr Neduzhko
30.09.2013 - 29.03.2018

Centers for Disease Control and Prevention (CDC)

This study assesses the effectiveness of the MARTAS - Modified effective “Anti-Retroviral Treatment and Access to Services” (ARTAS) intervention. This is a case management - based individual-level, multi-session intervention for people who are recently diagnosed with HIV in narcology, TB, and STIs clinics in order to help them link to and be retained in HIV care.

1. (Modifying ARTAS) - modify the ARTAS intervention protocol for using it with patients recently diagnosed with HIV in Ukraine based on the results of a formative study conducted in specialized healthcare facilities of the Dnipropetrovsk oblast.
2. (Piloting MARTAS) – explore feasibility, acceptability and quality of intervention through a pilot study conducted in three specialized healthcare facilities in the city of Mykolaiv for a group of up to 30 patients recently diagnosed with HIV.
3. (Evaluating MARTAS) – using the design of a randomized controlled study, evaluate the effectiveness of intervention at nine sites (specialized healthcare facilities) in three oblasts of Ukraine (Odesa, Mykolaiv and Dnipropetrovsk) by comparing the observed rates of engagement and retention in care of HIV positive participants from the intervention and control groups.
4. (Studying the perception of MARTAS) – study the perception of MARTAS by the recipients to determine the feasibility of its implementation and its future dissemination in the healthcare facilities of Ukraine.

Neduzhko O, Postnov O, Sereda Y, Kulchynska R, Bingham T, Myers JJ, Flanigan T, Kiriazova T. Modified Antiretroviral Treatment Access Study (MARTAS): A Randomized Controlled Trial of the Efficacy of a Linkage-to-Care Intervention Among HIV-Positive Patients in UkraineAIDS Behav. 2020 Apr 24 (EN)

Neduzhko O, Postnov O, Bingham T, Myers J, Flanigan T, Kiriazova T. Feasibility and Acceptability of the Modified Antiretroviral Treatment Access Study (MARTAS) Intervention Based on a Pilot Study in Ukraine. J Int Assoc Provid AIDS Care. 2019 Jan-Dec (EN)

Kiriazova T, Postnov OBingham TMyers JFlanigan TVitek C, Neduzhko O. Patient and provider perspectives inform an intervention to improve linkage to care for HIV patients in Ukraine. BMC Health Serv Res. Jan 30, 2018 (EN)
 
Copies of the MARTAS study dataset may be obtained by submitted a data request to Dr. Oleksandr Neduzhko. His current e-mail address is This email address is being protected from spambots. You need JavaScript enabled to view it.. All requests for data must be submitted with a plan describing the purpose of the data request and plans securing the data, and the plans release of the results. A data release committee will review the request. If that committee cannot be reconstituted at the time of the request, then Dr. Oleksandr Neduzhko will make the appropriate determination on his own.
 
Tetiana Kiriazova
13.04.2018 - 31.01.2019

World Health Organization

The study will look at the feasibility and impact of expanding the availability and accessibility of community management of opioid overdose (including training and take-home naloxone) in participating countries/sites.

The study will produce evidence on the implementation barriers and facilitators for community management of opioid overdose, including trainings, outreach activities and settings that are better placed to reach many people at risk to prevent opioid overdose. The initiative's targets include saving lives by making naloxone and training on overdose management available to all people likely to witness an overdose, including peers and family members. The initiative sets a global implementation target of 90-90-90 as a joint point of reference:

1) 90 per cent of the relevant target population should be trained in overdose risk and emergency management;

2) 90 per cent of those trained should carry take-home naloxone;

3) 90 per cent of those who have been given a naloxone supply should use naloxone at overdoses they witness.

Oleksandr Zeziulin
15.10.2018 - 15.04.2019

World Health Organization

Evaluation of changes of clinical practice of those primary health care workers who completed Essential Training on the Integrated Management of Hypertension and Diabetes in 7 pilot regions.

- To understand how the training was able to influence changes in PHC clinical practice in pilots in order to plan further improvements/adjustments of training’s content and teaching approaches, but also to identify other factors that need to be strengthened at PHC level for better NCDs prevention, early detection, care and support.;

- The evaluation of the project is planned to be carried out using three data collection approaches. Changes in risk assessment and treatment practices and outcomes will be evaluated by collecting information from patient records. Organizational changes in clinics and changes in division of tasks will be assessed performing observations of patient pathways. Focus group interview will be carried out to assess professionals’ opinions on effects of training in changing the practice and related possibilities and challenges.

Tetiana Kiriazova
01.07.2017- 30.06.2019

Johns Hopkins University

The proposed research project will explore the social and place-based context of injection drug use and HIV and HCV risk among people who inject drugs (PWID) in Ukraine. Study participants will include men and women 18 years of age and older in Dnipro, Ukraine.

Sergii Dvoriak
01.07.2017 - 10.08.2017
PACT, Inc.
The Initiative Center to Support Social Action "Ednannia"

Holding an international conference after the publication in the journal "The Lancet"

A two-day meeting in Kyiv (28-29 July, 2017) explored the range of possibilities to improve health services access for people who use drugs at three distinct time periods: pre-incarceration, incarceration and immediately post incarceration. The meeting focused on aligning current advocacy, policy directions and future research in EE&CA towards enhanced health and criminal justice outcomes for key stakeholders working across the interface of drug use, health service provision and criminal justice systems in the region. The meeting included a formal press event to cast a Ukrainian and EE&CA lens on challenges and opportunities in responding to the dual issues of drug policy and health in the criminal justice system in the region.

Tetiana Kiriazova
01.04.2017 - 31.03.2018
National Institute of Allergy and Infectious Diseases (NIAID)
National Institutes of Health (NIH)

Study of the aspects of stigma (as a barrier to HIV treatment) that can be changed through the development and implementation of interventions

Tetiana Kiriazova
01.03.2016 - 28.02.2017

National Institutes of Health (NIH), Harvard University

Collection of samples and observation of the growth of culture in dense nutrient media and incubation in test tubes with an indicator of growth of mycobacteria

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