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Tetiana Kiriazova
01.01.2019 - 31.12.2019

Johns Hopkins University

1. Empirically identify and characterize patterns of layered stigma (HIV, drug use, and gender-based) among drug using WLWH in Ukraine.

2. Examine the relationship between patterns of layered stigma identified through LCA and mental health outcomes and engagement in HIV care.

3. Qualitatively explore the association between layered stigma class, mental health, and engagement in HIV care.

Oleksandr Zeziulin
01.10.2018 - 31.01.2020

National Institute of Health

To develop and test a two-step shared decision-making (SDM) aid, with a focus on HIV+ PWID, to promote OAT entry and retention in PWID who have previously or never been prescribed OAT.

Sergii Dvoriak
01.07.2018 - 31.06.2019

National Institute on Drug Abuse (NIDA)

The aim of this project is to study the effectiveness of the modified SBIRT, where instead of offsite psychiatric referral, depression is treated onsite using SSRIs. Also, we will use ECHO (Extension for Community Healthcare Outcomes), a collaborative learning process, to facilitate mSBIRT activities and reinforce integration of COD services in OAT clinics.To enhance ECHO implementation, evidence-based pay-forperformance (P4P) intervention, aligned with Ukraine’s health reform, will be added to determine if incremental benefits are derived from this EBP, in an effort to strengthen and support ongoing healthcare reform efforts in Ukraine.

1. To compare both service-level (screening and brief intervention adoption and penetration) and patient-level (SSRI initiation, OAT drop-out and psychiatric quality of life) outcomes in 1,350 patients with opioid use disorders receiving OAT from 4 regions (clusters) and 12 clinical settings using a randomized, cluster-controlled design over 24 months. Before site randomization, all OAT clients at each participating site will have baseline assessments followed by site randomization to receive standard of care (N=450) versus integrated care using ECHO-COD facilitation with (N=450) or without (N=450) P4P incentives;

2. Using a multi-level implementation science framework, to examine the contribution of client, clinician and organizational factors that contribute to the primary and secondary outcomes;

3. To conduct a cost-effectiveness analysis (CEA) of integrating COD services into OAT clinics, with or without P4P, compared to a control group of OAT sites.

Tetiana Kiriazova
13.04.2018 - 31.01.2019

World Health Organization

The study will look at the feasibility and impact of expanding the availability and accessibility of community management of opioid overdose (including training and take-home naloxone) in participating countries/sites.

The study will produce evidence on the implementation barriers and facilitators for community management of opioid overdose, including trainings, outreach activities and settings that are better placed to reach many people at risk to prevent opioid overdose. The initiative's targets include saving lives by making naloxone and training on overdose management available to all people likely to witness an overdose, including peers and family members. The initiative sets a global implementation target of 90-90-90 as a joint point of reference:

1) 90 per cent of the relevant target population should be trained in overdose risk and emergency management;

2) 90 per cent of those trained should carry take-home naloxone;

3) 90 per cent of those who have been given a naloxone supply should use naloxone at overdoses they witness.

Tetiana Kiriazova
01.07.2017- 30.06.2019

Johns Hopkins University

The proposed research project will explore the social and place-based context of injection drug use and HIV and HCV risk among people who inject drugs (PWID) in Ukraine. Study participants will include men and women 18 years of age and older in Dnipro, Ukraine.

Tetiana Kiriazova
01.06.2017 - 31.05.2022

Fogarty International Center

The aim of this project is to strengthen UIPHP research and training capacity in the areas that are relevant to HIV epidemics in Ukraine. Some topic areas may be in HIV and infectious disease epidemiology; biostatistics; and implementation science, which may include program evaluation and health behavior as relates to HIV/HCV/TB/substance use.

Sergii Dvoriak
15.09.2016 - 30.06.2021

National Institute on Drug Abuse (NIDA)

The aim of this project is to study the effectiveness of the integrated model of health care services in primary care clinics and the interventions for quality improvement of health care services by means of training of physicians and their financial motivation

Sergii Dvoriak
01.08.2016 - 30.09.2019

Centers for Disease Control and Prevention (CDC)

The purpose of the project is to develop a coherent system of evaluation and quality improvement which can be used by institutions implementing opioid substitution therapy, as well as by national agencies responsible for the implementation and effectiveness of the program.

1. Development of the Adapted clinical guidelines and the Unified clinical protocol of healthcare services.
2. Development of the standard of healthcare services provision.
3. Development, recording and dissemination of video-trainigs for treatment of opioid dependence and comorbid diseases, provision of psychosocial support.
4. Development and piloting of the quality improvement system.
During the project period, the Adapted Clinical Guideline, the Unified Clinical Protocol of healthcare services and the Standard of healthcare services provision "Treatment of Mental and Behavioral Disorders due to the Use of Opioids" were developed. The developed documents are submitted for approval to the Ministry of Health of Ukraine.
In 2017 4 video courses for physicians, nurses, psychologists, and social workers were developed and recorded: 1. Treatment of opioid dependence; 2. Integrated care to people with mental and behavioral disorders due to the use of opioids; 3. Organizational aspects of providing integrated services to people with mental and behavioral disorders due to the use of opioids; 4. Psychosocial support for patients with opioid dependence in accordance with international recommendations and national standards. More than 500 clinicians and other healthcare workers were trained on Public Health Center of Ukraine online platform. 1st and 2nd courses were updated.
The concept of the quality assessment system is developed. It consists of the following components:
1. Regular analysis of data obtained through centralized electronic reporting (the concept has been developed and agreed with donor, implementation has been started on pilot sites)
2. Periodic external evaluation of quality indicators (a monitoring form has been developed and piloted)
3. Periodic sample evaluation of patient satisfaction (the patient satisfaction assessment questionnaire was developed and piloted)
Sergii Dvoriak
01.08.2015 - 31.07.2019

National Institute on Drug Abuse (NIDA)

To study the spread of socially dangerous infectious diseases, including HIV, viral hepatitis B and C, syphilis; injecting drug use, the use of other psychoactive substances and mental disorders not related to the use of PS among prisoners in Ukraine.

Frederick L Altice, Lyuba Azbel, Jack Stone, Ellen Brooks-Pollock, Pavlo Smyrnov, Sergii Dvoriak, Faye S Taxman, Nabila El-Bassel, Natasha K Martin, Robert Booth, Heino StÖver, Kate Dolan, Peter Vickerman.  The perfect storm: incarceration and the high-risk environment perpetuating transmission of HIV, hepatitis C virus, and tuberculosis in Eastern Europe and Central Asia. The Lancet. July 14, 2016. (EN)

Azbel L., Wickersham J.W., Wegman M., Polonsky M., Suleymanov M., Ismayilov R., Dvoryak S., Altice F.L. Burden of substance use disorders, mental illness, and correlates of infectious diseases among soon-to-be-released prisoners in Azerbaijan. Drug and Alcohol Dependence. 2015 Mar 19 (EN)

Polonsky, M.; Rozanova, J.; Azbel, L.; Bachireddy, C.; Izenberg, J.; Kiriazova, T.; Dvoryak, S.; Altice, F.L. Attitudes toward addiction, methadone treatment, and recovery among HIV-infected Ukrainian prisoners who inject drugs: Incarceration effects and exploration of mediators.  AIDS and Behavior. 2016 Dec; 20(12) (EN)

Azbel L., Grishaev, Y., Wickersham J.W., Chernova O., Dvoryak S., Polonsky, M., Altice F.L. Trials and tribulations of conduction bio-behavioral surveys in prisons: Implementation science and lessons from Ukraine. International Journal of Prisoner Health. 2016 Jun 13; 12(2) (EN)

Polonsky M, Azbel L, Wickersham JM, Marcus R, Doltu S, Grishaev E, Dvoryak S, Altice FL. Accessing methadone within Moldovan prisons: Prejudice and myths amplified by peers. Int J Drug Policy. 2016; 29 (EN)

Azbel L, Grishaev Y, Wickersham JA, Chernova O, Dvoryak S, Polonsky M, Altice FL. Trials and tribulations of conducting bio-behavioral surveys in prisons: implementation science and lessons from Ukraine. Int J Prison Health. 2016; 12(2) (EN)

Звіт про відвідування м. Суми групою дослідників за проектом «Співпраця із запобігання поширення ВІЛ в місцях позбавлення волі» УІПГЗ, 2018 (UA)

Oleksandr Zeziulin
01.06.2015 - 31.03.2019

The U.S. President's Emergency Plan for AIDS Relief (PEPFAR)

The purpose of this study was to test the effectiveness of two strategies: a community initiated treatment intervention (CITI) and MAT on HIV care enrollment and ART enrollment compared to the standard of care

1. Evaluation of the effectiveness of two strategies – Community-Initiated Treatment Intervention (CITI) and Medication-Assisted Treatment – and their impact on the rates of involvement of patients to HIV treatment programs and ART programs compared to Standard Care.
2. Identification of barriers associated with the client and the service provider, which impede the involvement of IDUs to HIV treatment programs, ART and also affect the rates of retention
3. Determination of the costs for each participant in the program, taking into account the breakdown of cost components within the cascade model, reflecting the results of ART for CITI and MAT

Abstract “Implementing large multisite experimental study in Ukraine” was presented at NIDA International Forum 2016